This course takes a holistic approach to analysing the factors involved in safe operation of advanced transport aircraft, beginning with a description of current accident statistics, and their analyses. The course includes an extensive description of advanced aircraft technology such as fly-by-wire and the interfaces between aircraft and crew such as electronic cockpit displays, heads-up displays, cockpit controls, and automation. The course reviews human performance issues such as cognition, mental models, situational awareness and desicion making from the perspective of flight crew. It concludes with and overview of current world best proctices for flight crew and aviation organisations. The course is intended for professional flight crew, aviation managers, equipment manufacturers, researchers, regulators and interested parties who would bebefit from a more complete knowledge of this complex area.